Key result
Butein suppresses proteinuria, lowers cholesterol, and reduces glomerular lesions in nephritic rats.
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Effects of butein on crescentic-type anti-glomerular basement membrane (GBM) nephritis in rats were investigated. When rats were treated with butein from 1 day after i.v. injection of anti-GBM serum, it inhibited the elevation of protein excretion into urine. In the butein-treated rats, cholesterol content in plasma was lower than that of the nephritic control rats. Histological observation demonstrated that this agent suppressed the incidence of crescent formation, adhesion of capillary wall to Bowman's capsule and fibrinoid necrosis in the glomeruli. Furthermore, butein suppressed the accumulation of leukocytes, including CD4-positive cells and CD8-positive cells in the glomeruli. However, butein failed to suppress the production of the antibody against rabbit gamma-globulin and the deposition of rat-IgG on the GBM. These results suggest that butein may be a useful medicine against rapidly progressive glomerulonephritis, which is characterized by severe glomerular lesions with diffuse crescents.
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Hayashi et al. (1996) studied Experimental crescentic-type anti-glomerular basement membrane (GBM) antibody-associated glomerulonephritis. Butein vs. Nephritic control rats was evaluated on Urinary protein excretion, plasma cholesterol content, and glomerular histological lesions (crescent formation, capillary wall adhesion, fibrinoid necrosis, leukocyte accumulation). Butein administered 1 day after anti-GBM serum injection inhibited urinary protein elevation, lowered plasma cholesterol, and suppressed glomerular crescent formation and leukocyte accumulation in rats.
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