icosanoids, particularly prostacyclin (PGI 2 ) and throm- boxane A 2 (TxA 2 ), have been implicated in the regulation of vascular homeostasis from the point of view of platelet-vessel wall interactions and in the regulation of blood vessel tone and hemostasis (for reviews, see references 1 and 2). However, subsequent investigations have revealed that PGI 2 and other eicosanoids may also have an important role in the regulation of arterial smooth muscle cell phenotype and cellular cholesterol metabolism. The purpose of this review is to summarize recent findings on the role of eicosanoids in the regulation of smooth muscle cell proliferative capacity and cellular cholesterol content under normal physiological conditions and in an "atherogenic" environment.
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Pomerantz et al. (1989) studied this question.