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Unsymmetric, N ‐substituted benzimidazoles and imidazopyridines can be prepared directly from 2‐halonitroarenes and amides through Pd(TFA) 2 /( R )‐BINAP‐catalyzed cross‐coupling and subsequent reductive aminocyclization. This sequence can be conducted by a one‐pot procedure. The method is versatile and allows the straightforward, regioselective preparation of these important nitrogen heterocycles.
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Alonso et al. (2010) studied this question.
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