Immunoglobulins with properties like those of human IgE (reaginic antibodies) occur in several laboratory animals, particularly the rat after antigenic injection (1, 2) or helminth infestation (3), the mouse after antigenic injection (4, 5) or helminth infestation (6), and the rabbit after antigenic injection (7, 8) and helminth infestation (9). Apart from a heat-labile antibody reported in guinea pigs infected with Trichinella spiralis (10), which conferred passive cutaneous anaphylactic (PCA) sensitivity on homologous skin for 21 days, reagin-like antibodies have not hitherto been described in guinea pigs, despite this animal's extreme susceptibility to anaphylaxis. Benacerraf and Ovary and their associates (11, 12) described two 7S immunoglobulins in guinea pigs, a γ1 which sensitized homologous tissues anaphylactically, and a γ2 which did not. The investigations described below now reveal at least three antibodies in guinea pig sera capable of sensitizing homologous tissues anaphylactically. The first is the γ1 globulin (12) that is heat-stable at 60°C, confers good PCA activity after a latent period of 4 hr, and persists in skin for 3 to 4 days. The second, a previously undescribed antibody, is closely associated with the γ1,1 globulin and shares some of its antigenic determinants, is heat-stable, gives little or no PCA sensitivity after a latent period of 4 hr, but strong sensitivity after 16 hr which persists for 7 and occasionally for 9 days. The third anaphylactic sensitizing antibody resembles reaginic antibodies in other species; it is heat-labile at 56°C after 1 hr and induces a sensitivity that persists for 28 days.
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W.E. Parish (1970) studied this question.