pH-responsive liposomes are prepared by conjugating glycol chitosan (GC) to the outer lipid membrane. This functionalization allows the liposomes to transition from a negative charge at physiologic pH to a positive charge in the acidic extracellular tumor microenvironment. Upon obtaining a positive charge, the GC-liposomes loaded with doxorubicin exhibited enhanced cellular uptake and improved anticancer efficacy.
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Yan et al. (2015) studied this question.
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