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August 13, 2026Epidemiology

The Role of Assignment in Defining and Identifying Causal Effects in Randomized Trials

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Overview

Randomized trial examines causal effects of treatment strategy in trials, highlighting assignment's importance.

Key Points

  • This examination focuses on how assignment influences causal estimands in randomized trials, specifically the per-protocol effect and the treatment strategy effect.
  • Analyzed causal structures of randomized trials with different causal estimands.
  • Discussed conditions for the equality of per-protocol effect and treatment strategy effect.
  • Identified the need for assignment information for proper causal estimation.
  • Clarified the distinction between per-protocol effect and treatment strategy effect.
  • Demonstrated that assignment must be considered for accurate causal effect estimation.
  • Highlighted situations where standard assumptions may not hold, affecting the validity of results.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d75d82b0e0cff3f63ebaehttps://doi.org/10.1097/ede.0000000000002034
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1On the distinction between the per-protocol effect and the effect of the treatment strategy2024 · 4 citations
  2. 2Instructing participants about the random assignment of patients to treated and non-treated conditions does not diminish causal illusions2025
  3. 3Causal inference methods for evaluating comparative effectiveness: target trial emulation2026
  4. 4Protocols for Observational Studies: Methods and Open Problems2024 · 1 citations
  5. 5Identification and Inference on Treatment Effects under Covariate-Adaptive Randomization and Imperfect Compliance2024