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August 13, 2026Intestinal ResearchOpen Access

Gut microbiome: a key driver and therapeutic target of intestinal fibrosis in Crohn’s disease

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Authors

JKJee Hyun KimYCYoon Jeong ChoiJYJun Hwan Yoo

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Overview

This review explores the microbiome's role in driving intestinal fibrosis in Crohn's disease, suggesting new therapeutic targets.

Key Points

  • The aim is to understand how the gut microbiome contributes to intestinal fibrosis in Crohn's disease and to explore potential therapeutic targets.
  • Reviewed evidence on microbial dysbiosis and its role in fibrogenesis.
  • Analyzed pathways involving fibroblast activation and immune responses.
  • Discussed therapeutic strategies targeting the microbiome.
  • Microbial dysbiosis is linked to increased intestinal fibrosis.
  • Expansion of pathobionts such as adherent-invasive Escherichia coli was highlighted.
  • Targeting the microbiome may offer new methods to prevent and reverse fibrosis in Crohn's disease.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76312b0e0cff3f63f50dhttps://doi.org/10.5217/ir.2026.00013
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