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August 11, 2026Obesity

Response to “Prepregnancy GLP ‐ 1 Receptor Agonist Use: Unaccounted Pretreatment BMI May Distort Obstetric Outcome Signals in Real‐World Studies”

Dominick J. Lemas Ruben Zapata Isaac Loy Aditya D Mahadevan Tony Wen Rahma Mkuu Adetola Louis‐Jacques Jaclyn Hall Kylie K. Harrall Larissa J. Strath Amy Sheer Elizabeth Shenkman Jingchuan Guo Michelle I. Cardel Steven M. Smith

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Key Points

Analyze the influence of prepregnancy GLP-1 receptor agonist use on obstetric outcomes while considering BMI.
No datasets were generated or analyzed during the study.
Focus on theoretical implications of unaccounted pretreatment BMI on outcomes.
Points to the necessity of accounting for BMI when assessing the effects of GLP-1 receptor agonists in obstetric contexts.

Implication

Examines obstetric outcomes linked to GLP-1 receptor agonist use, highlighting potential BMI effects.

Abstract

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Discussion

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Cite This Study

Lemas et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76502b0e0cff3f63f9e1 https://doi.org/10.1002/oby.70287

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Prepregnancy <scp>GLP</scp> ‐ <scp>1 Receptor Agonist</scp> Use: Unaccounted Pretreatment <scp>BMI</scp> May Distort Obstetric Outcome Signals in Real‐World StudiesOriginal Research · 2026
2Safety of <scp>GLP</scp> ‐1 and Dual <scp>GLP</scp> ‐1/ <scp>GIP</scp> Receptor Agonists in Preconception, Pregnancy, and Lactation: A Systematic Review of Maternal, Fetal, and Neonatal OutcomesSystematic Review · 2026 · 15 citations
3The Risk of <scp>GLP</scp> ‐1 Receptor Agonist ( <scp>GLP</scp> ‐1 <scp>RA</scp> ) Exposure in Early Pregnancy. A Call to Action: Quantifying the Impact on Pregnancy Outcomes in the <scp>United Kingdom</scp>Cohort Study · 2026 · 2 citations
4Prepregnancy <scp>GLP</scp> ‐ <scp>1RA</scp> Exposure and Risk of Hypertensive Disorders of Pregnancy Among Women With Obesity and DiabetesCohort Study · 2026 · 3 citations
5Glucagon‐Like Peptide‐1 Receptor Agonists in Pregnancy: Periconception Exposure and Perinatal OutcomesObservational Study · 2026

Exposure to <scp>GLP</scp>‐1 receptor agonists in early pregnancy did not increase the risk of congenital malformations2024
P-779 GLP-1 receptor agonist treatment in early pregnancy and risk of pregnancy complications - A nationwide cohort study2024
Glucagon-Like Peptide-1 Receptor Agonists and Risk of Adverse Maternal Pregnancy Outcomes2026
Daily 16:8 Versus Weekly 5:2 Intermittent Fasting for Weight Loss and Metabolic Health: A Randomized Controlled TrialObesity · 2026
Functional Characterization of CYP26B1 Short Isoform as a Novel Locus for Obesity in Indigenous Americans From ArizonaObesity · 2026

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