An exploratory evaluation of the clinical characteristics and treatment outcomes of patients diagnosed with chronic histiocytic intervillositis

INTRODUCTION: Chronic histiocytic intervillositis (CHI) is a rare placental lesion associated with an aberrant, noninfectious activation of the maternal immune response. Macrophages then accumulate within the intervillous space of the placenta, with associated adverse outcomes. This study aimed to describe clinical characteristics and treatment outcomes in subsequent pregnancies of patients diagnosed with CHI. METHODS: This retrospective exploratory analysis utilized data abstracted from electronic medical records at a single institution. Patients with at least one pregnancy diagnosed with CHI confirmed by placental histopathology reports were included. Patients with intervillositis of infectious origin were excluded. DISCUSSION: Patients who initiated immunomodulatory treatment in post-index pregnancies had an associated decrease in placental fibrin deposition and were associated with a higher rate of living children.