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August 13, 2026Open Access

Nanoparticles for Drug Delivery Across the Blood-Brain Barrier: A Comprehensive Review of Mechanisms, Platforms, and Translational Frontiers

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Authors

1P1Rohit Singh, 2*Dr. Nidhi Chauhan, 3Dr. Vaishali Patel, 4Rozina P. Pravin

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Overview

Comprehensive review evaluates nanoparticle platforms and mechanisms for drug delivery in CNS disorders, highlighting translational challenges.

Key Points

  • This review aims to explore the use of nanoparticles for drug delivery across the blood-brain barrier (BBB) in treating central nervous system disorders.
  • Examined structural biology of the neurovascular unit and BBB heterogeneity.
  • Discussed major nanoparticle platforms: lipid-based, polymeric, metallic/inorganic, and biomimetic.
  • Evaluated key transport mechanisms and advanced strategies for improving drug delivery across the BBB.
  • Engineered nanoparticles show promise in enhancing drug delivery efficiency across the BBB.
  • Identified critical barriers to clinical translation, including immunogenicity and regulatory hurdles.
  • Proposed a precision nanomedicine framework to facilitate successful clinical applications.

Cite This Study

1Rohit Singh, 2*Dr. Nidhi Chauhan, 3Dr. Vaishali Patel, 4Rozina P. Pravin (2026) studied this question.

synapsesocial.com/papers/6a7d76e62b0e0cff3f640b68https://doi.org/10.5281/zenodo.21884179
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