Changes in Serum Calcium, Serum Phosphate and Red-Cell Phosphate during Hyperventilation

IN their recent experiments on hyperventilation Saltzman et al.1 found no significant changes in the serum calcium, but in the early work on hyperventilation as a cause of tetany, Grant and Goldman2 observed an increase in the serum calcium in response to hyperventilation. Later, McCance3 reported a rise of the serum calcium of 0.5 mg. per 100 ml. during an episode of hyperventilation in 1 patient but no change in another.We have performed experiments on hyperventilation in 15 men (forceful hyperventilation for thirty minutes to produce the most severe tetany feasible). Data on 7 of these were reported earlier. . . .