Key result
Acute hypervolemic anemia increases cardiac output, whereas comparable hypervolemia without anemia shows no effect.
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Hypervolemia was produced in dogs by infusion of matched whole blood or of red cells suspended in dextran. In the dogs which had received matched whole blood, bleeding with simultaneous volume replacement with dextran produced acute hypervolemic anemia. This was associated with increased cardiac output, whereas no increase of cardiac output was seen in the same animals with a comparable amount of hypervolemia without anemia. The results suggest that anemia rather than hypervolemia was the important factor in causing an increase of cardiac output in these experiments.
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Fowler et al. (1958) studied Experimental hypervolemia with and without anemia. Acute hypervolemic anemia (bleeding with simultaneous dextran volume replacement after whole blood infusion) vs. Hypervolemia without anemia (matched whole blood or red cells suspended in dextran) was evaluated on Cardiac output. Acute hypervolemic anemia induced by dextran volume replacement in dogs increased cardiac output, whereas comparable hypervolemia without anemia caused no increase in cardiac output.
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