Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the "Seville Document".

Grade 1A recommendations We recommend: The use of restrictive transfusion strategies in nonbleeding, euvolaemic anaemic patients. Perioperative administration of tranexamic acid to patients undergoing cardiac surgery. The administration of intravenous iron to cancer patients, as an adjuvant to erythropoiesis-stimulating agents, for correcting chemotherapy-induced anaemia. Preoperative administration of erythropoiesisstimulating agents to anaemic, orthopaedic surgical patients expected to have moderate blood losses. We do not recommend: The administration of desmopressin to patients undergoing elective surgery. The administration of erythropoiesis-stimulating agents to critically ill patients who do not have a previous indication for this therapy.