Demonstrates stem cell-derived atrial engineered cardiac tissue recapitulating adult human myocardium contraction and ultrastructure, indicating utility for cardiovascular drug screening.
We demonstrate an atrial-like engineered cardiac tissue that recapitulates adult human atrial contraction for both kinetics and force production. Furthermore, we include numerous previously unmeasured ultrastructure metrics such as sarcomere alignment, cardiomyocyte anisotropy, and caveolae abundance. Our constructs may provide a human cardiac tissue platform for drug testing to identify combinatorial therapies to address atrial contractile dysfunction and diseases linked to cardiomyocyte ultrastructural defects.
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Turner et al. (2025) studied this question.
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