DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

Epigenetics can contribute to pathogenic mechanisms in autoimmunity. We recently identified an imprinted DNA methylation pattern in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) involving multiple genes in pathways implicated in cell migration, matrix regulation and immune responses.(1,2) To understand when alterations in DNA methylation occur in RA and the specificity of the methylation changes in RA, we compared differentially methylated loci (DMLs) of early RA (ERA), juvenile idiopathic arthritis (JIA) to longstanding RA (LRA) and osteoarthritis (OA). This article is protected by copyright. All rights reserved