Key result
Factor XI/XIa inhibitors demonstrated safety and the potential for reduced thrombotic events compared to currently available medications in phase 2 studies.
Why the study?
DOACs carry a persistent incidence of bleeding, prompting the need for agents such as FXI inhibitors that reduce bleeding risk while preventing and treating thromboembolism.
Do Factor XI/XIa inhibitors safely and effectively prevent venous and arterial thromboembolism compared to currently available medications?
Do Factor XI/XIa inhibitors safely and effectively prevent venous and arterial thromboembolism compared to currently available medications?
Factor XI/XIa inhibitors show promise in phase 2 trials for reducing thrombotic events with a lower risk of bleeding compared to current anticoagulants.
During the past decade, direct oral anticoagulants (DOACs) have advanced and simplified the prevention and treatment of venous thromboembolism (VTE). However, there remains a high incidence of bleeds, which calls for agents that have a reduced risk of bleeding. Factor XI (FXI) deficiency is associated with lower rates of venous thrombosis and stroke compared to the general population with a lower risk of bleeding. In conjunction with this, phase 2 studies have demonstrated safety and the potential for reduced thrombotic events with FXI inhibitors as compared to currently available medications. The aim of this review is to summarize key data on the clinical pharmacology of FXI, the latest developments in clinical trials of FXI inhibitors, and to describe the efficacy and safety profiles of FXI inhibitors for the prevention of venous and arterial thromboembolism.
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Prakash et al. (2023) conducted a review in venous and arterial thromboembolism. Factor XI/XIa inhibitors vs. currently available medications was evaluated. Factor XI/XIa inhibitors demonstrated safety and the potential for reduced thrombotic events compared to currently available medications in phase 2 studies.
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