Key result
Single-nucleotide polymorphisms in GPR133 were associated with RR interval (P=3.9x10^-8), and variants in NOS1AP (P=2.0x10^-10) and chromosome 13 (P=4.34x10^-8) were associated with QT interval.
Why the study?
Are specific common genetic variants associated with RR and QT interval duration in isolated European populations?
Observational (n=2,325)
Yes
Are specific common genetic variants associated with RR and QT interval duration in isolated European populations?
p-value: p=3.9 x 10(-8)
The study identifies GPR133 as a novel genetic determinant for RR interval and confirms NOS1AP's association with QT interval duration.
Variants in GPR133 and NOS1AP associate with RR/QT intervals; hypothesis-generating and should not yet alter clinical practice.
BACKGROUND: We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations. METHODS AND RESULTS: We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P=3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P=4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval. CONCLUSIONS: Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.
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Marroni et al. (2009) reported an observational. Single-nucleotide polymorphisms was evaluated on Length of the RR and corrected QT intervals (p=3.9 x 10(-8)). Single-nucleotide polymorphisms in GPR133 were associated with RR interval (P=3.9x10^-8), and variants in NOS1AP (P=2.0x10^-10) and chromosome 13 (P=4.34x10^-8) were associated with QT interval.
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