Key result
Rhinovirus A was the predominant species (109 isolates) followed by RV-C (80 isolates) among pediatric patients with community-acquired pneumonia in China.
Why the study?
Rhinoviruses are a major pathogen of community-acquired pneumonia in children, motivating an investigation into their prevalence and genetic characteristics in China.
Observational (n=209)
Yes
RV-A is the predominant rhinovirus species in Chinese children with community-acquired pneumonia, with high genetic conservation but specific mutations in neutralizing immunogenic sites.
Answers are grounded in this paper and cite their sources.
May inform regional CAP surveillance in Chinese children; hypothesis-generating for RV-A genetic variants and requires prospective validation.
Rhinoviruses (RVs) are a major pathogen of community acquired pneumonia in children. To investigate the prevalence and genetic characteristics of RVs in China, we performed a molecular epidemiological study during 2017-2019 in community acquired pneumonia (CAP) in pediatric patients. In this multicenter study, 109 RV-A, 20 RV-B and 80 RV-C were identified. Among them, RV-A12, RV-A101, RV-A78, RV-A49, RV-A22, RV-B52, RV-C2, RV-C53 and RV-C5 were the common genotypes in the study. A total of 23 complete genome of RVs including 4 RV-A, 1 RV-B and 18 RV-C were obtained. Furthermore, in the RV-C isolates, one RV-C5 and five RV-C53 genotypes were found, which have a limited number in the GenBank. Phylogenetic analysis of the complete genome showed that most of the RVs isolated in the study have high nucleotide sequence identities (>95%) compared with the corresponding reference sequence in the GenBank. In RV-A9, RV-A28, RV-A61 and RV-B52, amino acid mutations were found in the potential neutralizing immunogenic (Nim) sites (Nim-1a and Nim-1b) of the VP1. In RV-B52, one of RV-C2 and RV-C5 isolates, amino acid mutations were found in the P1a peptide of the VP1. However, no recombination events were found in the study. In conclusion, RV-A was the predominant specie of RVs followed by RV-C in the study. The complete genomes of one RV-C5 and five RV-C53 genotypes were obtained which have a limited number sequence in the GenBank. High nucleotide sequence identities (>95%) were found among the complete genome obtained in the study and the corresponding reference sequence in the GenBank. Amino acid mutations were found in the potential Nim-1a, Nim-1b sites and P1a peptide region of the VP1 in parts of RVs.
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Ai et al. (2022) conducted an observational in Community acquired pneumonia (n=209). Rhinovirus infection was evaluated on Prevalence and genetic characteristics of rhinoviruses. Rhinovirus A was the predominant species (109 isolates) followed by RV-C (80 isolates) among pediatric patients with community-acquired pneumonia in China.
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