Key result
Partial leptin reduction and higher adiponectin-to-leptin ratios show promise against obesity-associated cardiovascular disorders.
Why the study?
A paradox of high levels of both leptin and adiponectin is emerging in the pathogenesis of cardiovascular disorders, prompting a need to understand underlying mechanisms and potential therapeutic strategies.
Highlights the emerging paradox of high leptin and adiponectin levels in cardiovascular pathogenesis and suggests modulating their ratio as a therapeutic approach.
Answers are grounded in this paper and cite their sources.
Should not yet change clinical practice in obesity-related CVD; leaves open the therapeutic potential of leptin-adiponectin modulation for prospective trials.
The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a sophisticated and highly active endocrine organ, opening a new era of investigating adipose-mediated tissue crosstalk. Both obesity-associated hyperleptinemia and hypoadiponectinemia are important biomarkers to predict cardiovascular outcomes, suggesting a crucial role for adiponectin and leptin in obesity-associated cardiovascular disorders. Normal physiological levels of adiponectin and leptin are indeed essential to maintain proper cardiovascular function. Insufficient adiponectin and leptin signaling results in cardiovascular dysfunction. However, a paradox of high levels of both leptin and adiponectin is emerging in the pathogenesis of cardiovascular disorders. Here, we (1) summarize the recent progress in the field of adiponectin and leptin and its association with cardiovascular disorders, (2) further discuss the underlying mechanisms for this new paradox of leptin and adiponectin action, and (3) explore the possible application of partial leptin reduction, in addition to increasing the adiponectin/leptin ratio as a means to prevent or reverse cardiovascular disorders.
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A 2021 study conducted a review in Cardiovascular disorders and obesity. Adiponectin and leptin levels was evaluated on Cardiovascular disorders. Partial leptin reduction and increasing the adiponectin-to-leptin ratio are promising therapeutic strategies to prevent or reverse obesity-associated cardiovascular disorders.
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