Carbon−Proton Chemical Shift Correlation in Solid-State NMR by Through-Bond Multiple-Quantum Spectroscopy

A new two-dimensional NMR carbon−proton chemical shift correlation experiment, the MAS-J-HMQC experiment, is proposed for natural abundance rotating solids. The magnetization transfer used to obtain the correlations is based on scalar heteronuclear J couplings. The 2D map provides through-bond chemical shift correlations between directly bonded proton−carbon pairs in a way similar to that in corresponding high-resolution liquid-state experiments. The transfer through J coupling is shown to be efficient and more selective than those based on heteronuclear dipolar couplings. The experiment, which works at high MAS spinning frequencies, yields the unambiguous assignment of the proton resonances. The experiment is demonstrated on several organic compounds.