Why the study?
Does a six-hour rule-out protocol using serial CK-MB and continuous ST segment monitoring accurately exclude myocardial damage in patients with chest pain at low to moderate risk of myocardial infarction?
Population
383 consecutive patients aged over 25 years with chest pain of less than 12 hours' duration who were at low…
Comparison
Six hour rule-out protocol consisting of serial… vs Gold standard consisting of either a 48 hour…
Design
Cohort
Follow-up
48 hours
Authors
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Supports early rule-out in low-moderate risk chest pain; hypothesis-generating and should not yet change practice without randomized validation.
Does a six-hour rule-out protocol using serial CK-MB and continuous ST segment monitoring accurately exclude myocardial damage in patients with chest pain at low to moderate risk of myocardial infarction?
An emergency department-based six-hour rule-out protocol using serial CK-MB and continuous ST monitoring is highly sensitive and has a near-perfect negative predictive value for safely excluding myocardial infarction.
K R Herren (2001) studied this question.
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