Key result
Vascular-ventricular stiffening and abnormal arterial-cardiac interaction are important pathophysiological mechanisms in heart failure with preserved ejection fraction.
This review highlights the role of arterial-cardiac interaction and vascular-ventricular stiffening in the pathophysiology of heart failure with preserved ejection fraction.
Supports mechanistic research on arterial-cardiac coupling in HFpEF; does not yet alter clinical practice.
Vascular stiffening of the large arteries is a common feature of human aging. Increased aortic stiffness with age may contribute to pathological changes in the left ventricle and this can induce ventricular stiffening. Vascular-ventricular stiffening combined with abnormal arterial-cardiac interaction is considered an important pathophysiology of heart failure with a preserved ejection fraction. Here, I briefly review the concept and implications of arterial-cardiac interaction and this will pave the way to understanding and controlling heart failure with a preserved ejection fraction, which is more prevalent in the elderly.
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Chi Young Shim (2011) conducted a review in Heart failure with preserved ejection fraction. Arterial-cardiac interaction was evaluated. Vascular-ventricular stiffening and abnormal arterial-cardiac interaction are important pathophysiological mechanisms in heart failure with preserved ejection fraction.
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