Structural, Biochemical, and Biophysical Studies of HLA-A2/Altered Peptide Ligands Binding to Viral-peptide-specific Human T-cell Receptors

Signaling through the T-cell receptor (TCR) is requiredfor initiation of a cellular immune response. The ligandfor the TCR consists of a polymorphic class I or class IImajor histocompatibility (MHC) protein complexed withan antigenic peptide. The TCR thus differs from most cellsurface receptors in that it does not have a single conserved ligand...