Key result
Non-invasive pressure-strain loop indices, particularly global work efficiency, showed a strong negative correlation with ventricular end-diastolic pressure (r = -0.831, p < 0.001) in functional single ventricle patients.
Why the study?
Pressure-strain loop myocardial work indices effectively evaluate biventricular function, but have not been extensively investigated in functional single ventricle patients.
Does non-invasive pressure-strain loop echocardiography accurately assess ventricular end-diastolic pressure and differentiate functional single ventricle subtypes in patients with functional single ventricle?
Cross-Sectional (n=38)
No
Does non-invasive pressure-strain loop echocardiography accurately assess ventricular end-diastolic pressure and differentiate functional single ventricle subtypes in patients with functional single ventricle?
Non-invasive pressure-strain loop indices, particularly global work efficiency, strongly correlate with invasive ventricular end-diastolic pressure and can effectively evaluate cardiac function and subtype differences in functional single ventricle patients.
Answers are grounded in this paper and cite their sources.
May support non-invasive VEDP assessment in single ventricle; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: In biventricular circulation, myocardial work indices derived from pressure-strain loops (PSL) show potential for effectively evaluating ventricular function in both left and right ventricles. However, these novel myocardial work parameters have not been extensively investigated in patients with functional single ventricle (FSV). OBJECTIVES: To assess the relationship between myocardial work indices and parameters from cardiac catheterization in FSV patients, and to compare differences between functional single ventricle subtypes. METHODS: This retrospective study analyzed 38 FSV patients, including 17 with single left ventricle (SLV) patients and 21 with single right ventricle (SRV) patients. All patients underwent echocardiography and cardiac catheterization on the same day. To analyze correlations, Spearman’s rank correlation coefficient was applied, while receiver operating characteristic (ROC) curves were developed to evaluate predictive accuracy. RESULTS: Compared to SLV patients, SRV patients exhibited significantly higher global wasted work (GWW) (194.0 [132.5, 309.5] vs. 101.0 [66.5, 143.5] mmHg%, p = 0.012) accompanied by significantly reduced global work efficiency (GWE) (86.0% [81.5, 90.0] vs. 93.0% [89.5, 95.0], p = 0.004). In all FSV patients, global work index (GWI) (r=-0.540, p < 0.01), global constructive work (GCW) (r=-0.436, p < 0.01), and GWE (r=-0.831, p < 0.001) showed significant negative correlations with ventricular end-diastolic pressure (VEDP), while GWW demonstrated a significant positive correlation with VEDP (r = 0.738, p < 0.001). PSL parameters exhibited good intra- and inter-observer reproducibility and high predictive value for VEDP > 10 mmHg. CONCLUSIONS: Pressure-strain loop indices can effectively evaluate cardiac function in FSV patients and reveal functional differences between subtypes. Larger studies are needed to validate the value of these emerging indicators.
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Liao et al. (2025) conducted a cross-sectional in Functional single ventricle (n=38). Non-invasive pressure-strain loop (PSL) myocardial work indices vs. Cardiac catheterization parameters (VEDP) was evaluated on Correlation of Global Work Efficiency (GWE) with Ventricular End-Diastolic Pressure (VEDP) (r = -0.831, p=<0.001). Non-invasive pressure-strain loop indices, particularly global work efficiency, showed a strong negative correlation with ventricular end-diastolic pressure (r = -0.831, p < 0.001) in functional single ventricle patients.
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