Lots, fast: Benzo[c]phenanthridine derivatives are prepared efficiently by the reaction of aldehydes and 2-methylbenzonitrile in the presence of potassium tert-butanolate, followed by dehydration (see scheme). Some of these compounds demonstrate excellent cytostatic activity, and it is possible to introduce substituents directly into the basic molecular ring system.
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Clement et al. (2004) studied this question.
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