Key result
CT angiography detected significant differences in pulmonary vascular, cardiac, and lung parenchyma changes in patients with PH, PE, or CTEPH compared to normal controls (p ≤ 0.01).
Why the study?
Does CT angiography identify significant differences in pulmonary and cardiac segments between patients with PH/PE/CTEPH and normal controls?
Observational (n=150)
Does CT angiography identify significant differences in pulmonary and cardiac segments between patients with PH/PE/CTEPH and normal controls?
CT angiography effectively identifies significant pulmonary vascular, cardiac, and parenchymal changes in patients with pulmonary hypertension, PE, and CTEPH compared to healthy controls.
May support CTA differentiation in suspected PH/PE/CTEPH; leaves open prospective validation before clinical adoption.
Pulmonary hypertension (PH) is a complex disorder and may be related to a variety of diseases. It may arise in association with chronic thromboembolic pulmonary hypertension (CTEPH) or pulmonary embolism (PE). Knowledge of the radiological features is required to characterize and accurately diagnose the conditions and may improve the outcome. This study was designed to evaluate the clinical characteristics and the computerized tomography angiography findings in patients with PH, PE and CTEPH. Contrast-enhanced CT scans were acquired in 55 Sudanese patients with PE, 20 patients with PH, 25 patients with CTEPH and 50 normal subjects who were considered as control group. The CT diagnostic criteria for all cases were characterized. The clinical signs, parenchymal abnormalities, pulmonary tree and cardiac segments in all groups were characterized and compared with the control group. The results showed that the most common clinical characteristics were found to be chest pain, dyspnea, lower limb swelling, tachycardia and syncope which were correlated significantly with the presence of the disease. In all patients groups, the pulmonary vascular segments, cardiac segments and lung parenchyma changes were detected and were significantly different from the normal control subjects at p ≤ 0.01. It was found that CT angiography has a significant role in the diagnostic evaluation of these groups of patients. CT imaging is acceptably used in diagnosis, defining cause, quantifying heart segments and parenchyma changes in order to assess the feasibility of surgery, monitoring and therapeutic planning.
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Aloub et al. (2016) conducted an observational in Pulmonary hypertension, pulmonary embolism, and chronic thromboembolic pulmonary hypertension (n=150). Contrast-enhanced CT angiography vs. Normal subjects was evaluated on Pulmonary vascular segments, cardiac segments and lung parenchyma changes (p=≤ 0.01). CT angiography detected significant differences in pulmonary vascular, cardiac, and lung parenchyma changes in patients with PH, PE, or CTEPH compared to normal controls (p ≤ 0.01).
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