Key result
The minor allele 'A' of the SCN10A common variant rs6795970 (V1073) was strongly associated with an increased risk of Brugada syndrome (OR 2.955) compared to population controls.
Why the study?
Common and rare SCN10A variants are suggested to contribute to Brugada syndrome, but the role of SCN10A common variants required characterization.
Are common variants in the SCN10A gene associated with increased susceptibility to Brugada syndrome?
Population
197 patients diagnosed with BrS
Comparison
Patients carrying each of four common variants associated with BrS
Design
Clinical, genetic, and cellular electrophysiological study
Authors
Loading...
May inform SCN10A inclusion in Brugada genetic panels; leaves open replication and functional validation before clinical use.
Case-Control (n=197)
No
Are common variants in the SCN10A gene associated with increased susceptibility to Brugada syndrome?
Odds Ratio: 2.955 (95% CI 2.414–3.618)
Absolute Event Rate: 55.6% vs 29.7%
p-value: p=5.161E-28
Common variants in the SCN10A gene, particularly rs6795970 (V1073), are associated with increased susceptibility to Brugada syndrome due to altered sodium channel electrophysiology.
Huang et al. (2021) conducted a case-control in Brugada syndrome (n=197). SCN10A common variant rs6795970 (minor allele A) vs. Controls from Exome Sequencing Project (ESP) was evaluated on Susceptibility to Brugada syndrome (OR 2.955, 95% CI 2.414-3.618, p=5.161E-28). The minor allele 'A' of the SCN10A common variant rs6795970 (V1073) was strongly associated with an increased risk of Brugada syndrome (OR 2.955) compared to population controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: