Key result
Advancing menopause stages and lower estradiol levels were associated with reduced shear-mediated dilation of the internal carotid artery, independent of age.
Why the study?
The study evaluated the effects of the menstrual cycle and menopause stages on shear-mediated dilation of the internal carotid artery as an index of cerebrovascular endothelial function.
Do menstrual cycle phases and menopause stages affect shear-mediated dilation of the internal carotid artery in women?
Observational
Do menstrual cycle phases and menopause stages affect shear-mediated dilation of the internal carotid artery in women?
Lower estradiol levels across menstrual cycle phases and advancing menopause stages are associated with reduced cerebrovascular endothelial function as measured by ICA shear-mediated dilation.
Association suggests menopause-related cerebrovascular endothelial changes; hypothesis-generating and requires confirmation before clinical consideration.
The present study evaluated the effects of the menstrual cycle and menopause stages on the shear-mediated dilation of the ICA, a potential index of cerebrovascular endothelial function, in pre-, peri-, and postmenopausal women. Shear-mediated dilation of the ICA was increased from the low- to high-estradiol phases in naturally cycling premenopausal women and was reduced with advancing menopause stages. Furthermore, lower estradiol was associated with reduced shear-mediated dilation of the ICA, independent of age.
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Iwamoto et al. (2020) conducted an observational in Menopause and menstrual cycle stages. Menstrual cycle phases and advancing menopause stages (estradiol levels) vs. Low-estradiol phases or earlier menopause stages was evaluated on Shear-mediated dilation of the internal carotid artery (ICA). Advancing menopause stages and lower estradiol levels were associated with reduced shear-mediated dilation of the internal carotid artery, independent of age.
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