An organocatalytic oxidative synthesis of N ‐protected tetrahydroisoquinolines is described by C–H functionalization via intermediate peroxides. The peroxides were synthesized from tert ‐butylhydroperoxide under metal‐free thermal conditions and were converted into the final products by Brønsted acid catalyzed substitution. The nucleophile scope was investigated in detail and proved to be broad; N ‐deprotection of the coupling products could also be achieved.
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Schweitzer‐Chaput et al. (2012) studied this question.
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