Catalytic Enantioselective tert‐Aminocyclization by Asymmetric Binary Acid Catalysis (ABC): Stereospecific 1,5‐Hydrogen Transfer

Selective H transfer by ABC: A new asymmetric binary acid catalyst was developed to promote 1,5-H transfer specifically and stereoselectively in tert-aminocyclization reactions with excellent activity, high enantioselectivity, and broad substrate scope. The H atom (in red) was proven to transfer through a stereospecific suprafacial pathway (see scheme).