Cytotoxic Sesquiterpenoids from Ammoides atlantica Aerial Parts

High Resolution Image Download MS PowerPoint Slide Seven new terpenoids, namely, guaiane ( 1 – 4 ), eudesmane ( 5 ), and bisabolane ( 6 ) sesquiterpenoids and a furanone ( 7 ), were isolated from the aerial parts of Ammoides atlantica, a herbaceous plant growing in Algeria, together with eight known compounds. All metabolites were characterized by their 1D and 2D NMR and HRESIMS data. A combined DFT/NMR method was applied to study the relative configurations of 1 – 4, 6, and 7 . All compounds, except 2, were assayed against MCF-7, A375, A549, HaCaT, and Jurkat cell lines. Compounds 8, 10, and 11 induced a dose-dependent reduction in cell viability with different potency on almost all cell lines used. The most active compounds, 8 and 10, were studied to assess their potential apoptotic effects and cell cycle inhibition.