I. A STUDY OF THE CALCIUM CONTENT OF HUMAN BLOOD SERUM IN HAY-FEVER, HYPERESTHETIC RHINITIS AND THE ASTHMAS In 1917, Halverson, Mohler and Bergeim1 of Philadelphia presented data with regard to the calcium content of the blood in a variety of pathologic conditions. While a rather wide field had been covered, no mention was made of hay-fever, hyperesthetic rhinitis, (vasomotor rhinitis) or the asthmas. This was probably due to the fact that these diseases were accepted as belonging to an entirely different field, and no possible relationship was suggested between them and the calcium deficiency of the blood. A thorough review of the literature gives one no added information regarding these conditions. This study was therefore undertaken to determine what relationship existed, if any, between hay-fever and hyperesthetic rhinitis and an ionic calcium deficiency of the human blood serum. Determination of Calcium in Blood Serum. —The problem of measuring the
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Novak et al. (1923) studied this question.
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