Why the study?
Do loratadine and terfenadine differentially suppress cardiac K+ channels in ventricular myocytes and Xenopus oocytes?
Population
Rat and guinea pig ventricular myocytes, and Xenopus oocytes expressing the HERG delayed rectifier
Comparison
Terfenadine, loratadine, and… vs Comparative effects between the drugs
Design
Preclinical
Authors
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Terfenadine's K+ channel blockade may underlie clinical QT effects; leaves open whether loratadine is safer in humans.
Do loratadine and terfenadine differentially suppress cardiac K+ channels in ventricular myocytes and Xenopus oocytes?
Terfenadine strongly suppresses cardiac K+ channels, particularly I(Kr), providing a mechanistic explanation for its association with QT prolongation, whereas loratadine lacks these effects.
Ducic et al. (1997) studied this question.