Why the study?
Does losartan improve bronchial hyperresponsiveness to methacholine in patients with stable asthma?
Does losartan improve bronchial hyperresponsiveness to methacholine in patients with stable asthma?
Losartan significantly reduces bronchial hyperresponsiveness to methacholine in asthmatic patients, demonstrating the involvement of AT1 receptors in bronchial asthma.
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Losartan may be considered for asthmatic patients needing antihypertensives; extends AT1 blockade evidence to airway hyperresponsiveness.
Myou et al. (2000) studied this question.
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