A Clinical Evaluation of Plasma Thromboplastin Antecedent (PTA) Deficiency

Article1 May 1965A Clinical Evaluation of Plasma Thromboplastin Antecedent (PTA) DeficiencyFRED G. CONRAD, WILLIAM L. BRENEMAN, DOROTHY B. GRISHAM, B.S.FRED G. CONRADSearch for more papers by this author, WILLIAM L. BRENEMANSearch for more papers by this author, DOROTHY B. GRISHAM, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-885 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Rosenthal, Dreskin, and Rosenthal (1) first described plasma thromboplastin antecedent (PTA) deficiency 10 years ago, investigators from numerous hematology centers have emphasized the infrequent occurrence of this defect. Reports of the relative rate of occurrence of patients deficient in antihemophilic factor (AHF) and plasma thromboplastin component (PTC) are remarkably stable at a 4 to 1 ratio in this country and throughout the world (2-4). The reports of relative occurrence of PTA show marked variations from less than 1% to 18% of the total thromboplastinogen disorders (5-8).Contrary to the usually reported low incidence, our studies indicate that PTA deficiency...References1. ROSENTHALDRESKINROSENTHAL RLOHN: New hemophilia-like disease caused by a deficiency of a third plasma thromboplastin factor. Proc. Soc. Exp. Biol. Med. 82: 171, 1953. CrossrefMedlineGoogle Scholar2. WINTROBE MM: Clinical Hematology, 5th ed., Lea & Febiger, Philadelphia, 1961, p. 877. Google Scholar3. EGBERG O: A family of antihemophilic C factor (AHC-PTA) deficiency with bleeding tendency. Scand. J. Clin. Lab. Invest. 14: 478, 1962. CrossrefGoogle Scholar4. BIGGSMACFARLANE RRG: Hemophilia and related conditions: a survey of 187 cases. Brit. J. Haemat. 4: 1, 1958. CrossrefMedlineGoogle Scholar5. RATNOFFMARGOLIS ODA: On the epidemiology of hemophilia and Christmas disease. New Eng. J. Med. 256: 845, 1957. CrossrefMedlineGoogle Scholar6. 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RATNOFFDAVIEMALLETT ODEWDL: Studies on the action of Hageman factor: evidence that activated Hageman factor in turn activates PTA. J. Clin. Invest. 40: 803, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lackland Air Force Base, TexasFrom the Department of Medicine, Wilford Hall U. S. Air Force Hospital, Aerospace Medical Division, Lackland Air Force Base, Tex.Requests for reprints should be addressed to Maj. Fred G. Conrad, USAF (MC), Wilford Hall USAF Hospital, Lackland AFB, Tex. 78236. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFactor XI deficiency disclosed following haemorrhage related to a dental extraction. Brief review and case reportCoronary Artery Bypass in Hereditary Factor XI Deficiency7 Transfusion Support for Congenital Clotting Deficiencies Other than HaemophiliaPartial Thromboplastin Time for ScreeningN.G. BARANETSKY, M.D., PAUL WEINSTEIN, M.D.Factor XI Deficiency: Detection and Management During Urological SurgeryProstatectomy in Factor XI DeficiencySurface Activity in Blood Coagulation 1 May 1965Volume 62, Issue 5Page: 885-898KeywordsAdenosine triphosphateBlood plasmaHematology and oncologyHospital medicineRisk management Issue Published: 1 May 1965 PDF downloadLoading ...