Why the study?
Does promethazine reduce ischemic and reperfusion arrhythmias in isolated perfused rat hearts?
Does promethazine reduce ischemic and reperfusion arrhythmias in isolated perfused rat hearts?
Promethazine reduces ischemic and reperfusion arrhythmias in rat hearts, likely via nonspecific membrane stabilization and enhanced coronary flow.
Should not change clinical arrhythmia management; leaves open whether membrane stabilization extends to human ischemia-reperfusion models.
The effects of the H1-receptor antagonists promethazine, mepyramine, and chlorpheniramine on ischemic and reperfusion arrhythmias were studied in the isolated perfused rat heart. Promethazine reduced both ischemic and reperfusion arrhythmias (2 x 10(-6)M-7.5 x 10(-6)M). Mepyramine and chlorpheniramine decreased these arrhythmias but at concentrations about 10 times higher. The H2-blockers cimetidine and ranitidine had no antiarrhythmic effect. Promethazine also: (i) increased release of noradrenaline by the heart; and (ii) increased coronary flow in the reperfusion period and in some mildly ischemic zones. It is proposed that promethazine exerts most of its antiarrhythmic effects by a nonspecific mechanism, possibly membrane stabilization; in addition, enhanced coronary flow may play a role.
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Rochette et al. (1988) studied this question.
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