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December 11, 1998British Journal of CancerOpen Access

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

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Authors

JAJudith van AsperenUCB Pharma (Belgium)OTOlaf van TellingenDutch Cancer SocietyFTFrank Tijssen

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Cite This Study

Asperen et al. (1998) studied this question.

synapsesocial.com/papers/6a7db0c5d491aa75eb150891https://doi.org/10.1038/sj.bjc.6690019
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Also Consider

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  3. 3Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.1988 · 356 citations
  4. 4Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice1996 · 176 citations
  5. 5Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.1995 · 1,116 citations