Pain is one of the most common symptoms of advanced cancer and has significant adverse effects on patients' functioning and quality of life. 1 A number of studies have established that pain can be controlled in the majority of patients using the World Health Organization (WHO) guidelines, 2 however, even when background pain is well controlled, 70–90 per cent of patients with advanced cancer also experience brief episodes or flares of severe pain, known as breakthrough pain. 3 Copyright © 2008 John Wiley & Sons, Ltd.
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Giovambattista Zeppetella (2008) studied this question.
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