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August 19, 2019British Journal of Pharmacology30 citationsOpen Access

Mind the gap (junction): cGMP induced by nitric oxide in cardiac myocytes originates from cardiac fibroblasts

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Population

Cardiac myocytes and fibroblasts isolated from knock-in mice expressing a FRET-based cGMP indicator

Design

Preclinical

Key result

NO-induced cGMP formed in cardiac fibroblasts enters cardiac myocytes via gap junctions, a process that is abolished by gap junction inhibitors.

Authors

LMLukas MengesCKChristian KrawutschkeEFErnst‐Martin Füchtbauer

Discussion

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Overview

Does not support clinical translation; leaves open in vivo relevance of fibroblast-myocyte cGMP transfer.

Structured PICO

P
Population
Cardiac myocytes and fibroblasts isolated from knock-in mice expressing a FRET-based cGMP indicator
I
Intervention
NO-GC-activating substances (NO, GC activators, and GC stimulators) and gap junction inhibitors
O
Outcome
cGMP signals in cardiac myocytes and fibroblastssurrogate

NO-induced cGMP formed in cardiac fibroblasts enters cardiac myocytes via gap junctions, acting as an intercellular signaling molecule.

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Cite This Study

Menges et al. (2019) studied this question. NO-GC-activating substances was evaluated on cGMP signals in cardiac myocytes and fibroblasts. NO-induced cGMP formed in cardiac fibroblasts enters cardiac myocytes via gap junctions, a process that is abolished by gap junction inhibitors.

synapsesocial.com/papers/6a7db949603f5e16dd33a266https://doi.org/10.1111/bph.14835
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE32023 · 9 citations
  2. 2NO-induced cGMP in the heart: Role of phosphodiesterases in physiology and pathophysiology2024
  3. 3Tissue-specific regulation of NO-GC isoforms in the cardiovascular system2025 · 2 citations
  4. 4NO/cGMP: The Past, the Present, and the Future2013 · 38 citations
  5. 5NO-sensitive guanylyl cyclase and NO-induced feedback inhibition in cGMP signaling2005 · 15 citations