Key result
In treatment-naïve HIV patients, NT-proBNP levels correlated with CD4 counts (r=-0.31, P<0.001) and viral load (r=0.26, P<0.001), an association that reversed after viral suppression.
Why the study?
Does antiretroviral therapy reduce NT-proBNP levels in ART-naïve HIV-infected patients?
Cohort (n=219)
Does antiretroviral therapy reduce NT-proBNP levels in ART-naïve HIV-infected patients?
Effect estimate: r = -0.31 for CD4 count; r = 0.26 for viral load
p-value: p=<0.001
Antiretroviral therapy reverses the subclinical elevation of NT-proBNP associated with uncontrolled HIV infection, suggesting an improvement in subclinical myocardial stretch.
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Supports ART to reduce subclinical myocardial stress in HIV; leaves open impact on clinical events.
Schuster et al. (2016) conducted a cohort in HIV infection (n=219). Antiretroviral therapy and viral suppression vs. Baseline (before antiretroviral therapy) was evaluated on Correlation of NT-proBNP with absolute CD4 cell count and HIV viral load (r = -0.31 for CD4 count; r = 0.26 for viral load, p=<0.001). In treatment-naïve HIV patients, NT-proBNP levels correlated with CD4 counts (r=-0.31, P<0.001) and viral load (r=0.26, P<0.001), an association that reversed after viral suppression.
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