Key result
Sildenafil citrate (50 mg) increased the mean velocity of left anterior descending coronary artery flow at 60 minutes in healthy male volunteers without systemic pressure drops.
Why the study?
Does sildenafil citrate affect coronary flow and systemic blood pressure in healthy male subjects?
Does sildenafil citrate affect coronary flow and systemic blood pressure in healthy male subjects?
A 50 mg dose of sildenafil citrate induces coronary vasodilatation without causing systemic blood pressure drops in healthy men.
May support coronary vasodilation without hypotension in healthy men; leaves open effects in patients with cardiovascular disease.
BACKGROUND: The purpose of this study was to evaluate the effect of sildenafil citrate (Viagra) on coronary function in normal subjects. METHODS: The study assessed mean blood pressure, left anterior descending coronary artery (LAD) flow, and echocardiographic variables before and 30 and 60 minutes after taking 50 mg of sildenafil citrate. The mean velocity of LAD flow was assessed with Doppler flow imaging. The study subjects were 6 healthy male volunteers (mean age 37 years). RESULTS: The mean velocity of LAD flow increased 60 minutes after taking sildenafil citrate, but there were no other changes. Two volunteers felt mild flashing and one had mild headache during the study. CONCLUSION: Sildenafil citrate caused vasodilatation in a normal coronary artery without systemic pressure drops. These results suggest that the agent itself did not have negative effects on the heart in normal subjects.
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Ishikura et al. (2007) studied Healthy (n=6). Sildenafil citrate was evaluated on Mean blood pressure, left anterior descending coronary artery (LAD) flow, and echocardiographic variables. Sildenafil citrate (50 mg) increased the mean velocity of left anterior descending coronary artery flow at 60 minutes in healthy male volunteers without systemic pressure drops.
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