Reporting live: Triplex formation is used to construct a stem–loop probe, which is opened upon binding of the DNA target (red). The triplex molecular beacon is composed of a single DNA strand (blue), a stem-forming oligomer (black), and is labeled with a fluorophore and a quencher (red and blue circles). This concept facilitates the introduction of further functionalities such as additional quenchers in the assembly of “superquenched” beacons.
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Grossmann et al. (2007) studied this question.
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