A homogeneous sensor: A new method for the detection of DNA is described. The approach is based on the high surface sensitivity provided by surface-plasmon-enhanced fluorescence spectroscopy and on the different electrostatic properties of peptide nucleic acids (PNAs) and DNA (see scheme). Immobilization of the DNA probes on the sensor surface is not required, which may reduce the complexity and costs of sensor preparation.
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Chu et al. (2007) studied this question.
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