Treatment of Familial Periodic Hypokalaemia With Propranolol (Inderal ®)

Four patients suffering form familial periodic paralysis with hypokalaemia (FPP) were subjected untreated to standardized induction of paralysis. The induction was repeated after pre-treatment with the beta receptor blocker propranolol (Inderal). In three of the patients propranolol had no or even a negative effect upon the development of paralysis or upon the fall in serum potassium. In one patient a slight prophylactic gain was achieved. It was not possible to demonstrate any difference in the serum level of glucose or insulin during the induction of paralysis according to whether the patients were untreated or treated with propranolol. Short-lasting out-patient treatment of the patient who had apparently had some slight prophylactic benefit from propranolol had to be discontinued after 11 days because of an unusually severe and long-lasting attack. It is concluded that propranolol has no major effect in the treatment of FPP-unlike its favourable effect in thyrotoxic familial periodic paralysis (TFPP).