Cross-sectional study reveals increased constipation, elevated inflammation, and impaired immune function in IBD patients with visceral obesity, highlighting metabolic risks in bowel disease.
OBJECTIVE: Obesity has gained attention among patients with inflammatory bowel disease (IBD). The impact of visceral obesity on chronic constipation, inflammation, immune function and cognition after diagnosis of IBD is still unknown. METHODS: This is a cross-sectional study of 150 IBD patients. Patients' visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured and were grouped according to visceral obesity. The potential impact of visceral obesity on cognitive function were evaluated using Mini-Mental State Examination. We evaluated patients' incidence of chronic constipation, levels of interleukin-6 (IL-6), T cells and body mass index in two groups. CONCLUSIONS: IBD patients had high risks of visceral obesity. CD Patients with visceral obesity had higher prevalence of chronic constipation, higher inflammation levels, decreased immune function.
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Wan et al. (2021) studied this question.
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