Key result
A stable-high continuous metabolic syndrome score trajectory during childhood was significantly associated with a 5.57-fold increased risk of elevated hs-CRP in adolescence compared to a stable-low trajectory.
Why the study?
The study sought to explore whether childhood continuous metabolic syndrome score trajectories are associated with hs-CRP and carotid intima-media thickness in adolescence.
Does a stable-high continuous metabolic syndrome score trajectory in childhood increase the risk of elevated hs-CRP and CIMT in adolescence?
Cohort (n=833)
No
Does a stable-high continuous metabolic syndrome score trajectory in childhood increase the risk of elevated hs-CRP and CIMT in adolescence?
Consistently high metabolic syndrome scores during childhood are associated with elevated systemic inflammation (hs-CRP) in adolescence, highlighting the need for early metabolic risk intervention.
Supports tracking childhood cMetS trajectories; hypothesis-generating for early interventions targeting adolescent inflammation.
We explored the association between the trajectory of the continuous metabolic syndrome score (cMetS) in childhood with high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT), which are known to increase cardiovascular disease risk in adolescence. The trajectory of cMetS in childhood (from 3 to 12 years of age) was identified in 833 children who participated in the Ewha Birth and Growth Study. The associations between cMetS and hs-CRP and CIMT were analyzed in 204 out of 833 children who participated in the follow-up at 13-15 years of age and measured hs-CRP and CIMT. Among the 833 children, three groups were classified: cMetS maintained at a low level (n = 198, 23.77%), middle level (n = 530, 63.63%), and at high levels (n = 105, 12.61%). The group with a stable-high cMetS trajectory showed significantly higher hs-CRP levels, and the statistical significance was maintained after adjusting for covariates. This study found that a consistently high cMetS in childhood was significantly associated with higher hs-CRP levels in adolescents, suggesting that it is necessary to intervene in metabolic risk factors early in life to reduce the risk of cardiovascular disease later in life.
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Choi et al. (2021) conducted a cohort in Metabolic Syndrome and Cardiovascular Risk (n=833). Stable-high continuous metabolic syndrome score (cMetS) trajectory vs. Stable-low cMetS trajectory was evaluated on Elevated high-sensitivity C-reactive protein (>0.3 mg/dL) at 13-15 years of age (OR 5.57, 95% CI 1.76-17.56). A stable-high continuous metabolic syndrome score trajectory during childhood was significantly associated with a 5.57-fold increased risk of elevated hs-CRP in adolescence compared to a stable-low trajectory.
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