Key result
A patient with Lynch syndrome carrying an MSH2 pathogenic variant developed a rare primary malignant pericardial tumour, suggesting a broader multi-tumour spectrum for this genetic condition.
Population
A 57-year-old woman with Lynch syndrome and previous ovarian cystadenocarcinoma
Design
Case report
Authors
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May warrant cardiac symptom vigilance in MSH2 carriers; leaves open whether primary cardiac sarcomas belong to the Lynch spectrum.
Case Report (n=1)
No
This case represents the first report of a malignant primary cardiac tumour in a patient with Lynch Syndrome, suggesting that MSH2 pathogenic variants may cause a more complex multi-tumour syndrome and warranting focused cardiac evaluation for symptoms like dyspnoea.
Paolisso et al. (2020) conducted a case report in Lynch syndrome with primary malignant pericardial tumour (n=1). MSH2 pathogenic variant was evaluated. A patient with Lynch syndrome carrying an MSH2 pathogenic variant developed a rare primary malignant pericardial tumour, suggesting a broader multi-tumour spectrum for this genetic condition.
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