Summary : A clinical study of the use of medroxyprogesterone acetate as a method of contraception, administered as 6‐monthly intramuscular injections of 300 mg., was carried out in 61 women. A total of 989 months of study were completed and 14 women received 4 injections or more. There were no significant changes in the systolic and diastolic pressure or in the body weight during 18 months of observation as compared with the pre‐treatment levels. Disorganisation of the uterine bleeding pattern was encountered, particularly during the first 6 months. However, there was a progressive decrease in the duration of bleeding per month and increase in the proportion of women who had amenorrhoea with time. Side‐effects were varied but mild; depression and diminution in libido were comparatively common. No pregnancy occurred during the period of study. Twenty of the 61 women discontinued treatment for reasons related to the drug, the important factor in 75% of the drop‐outs was unacceptable bleeding.
No takes yet. Share an insight, caveat, or question.
Mackay et al. (1971) studied this question.