CONNECT4 APOE : A randomized trial of telephone versus real‐time two‐way videoconference for disclosure of APOE genotype results in cognitively unimpaired adults

INTRODUCTION: Data are needed to inform best practices for disclosing apolipoprotein E (APOE) results given increasing indications for testing. METHODS: CONNECT4, a multi-center, randomized trial (NCT02978729) compared disclosure of APOE genotype by videoconference or telephone among cognitively unimpaired adults 60-75 years of age. Outcomes were collected at baseline, 2-7 days, 6 weeks, and 6 months. RESULTS: A total of 301 participants were randomized to telephone and 297 to videoconference disclosure. There were no significant differences between arms for primary or secondary patient-reported outcomes. Moderator analyses found that videoconference reduced depressive symptoms more for older participants (70-75 year), whereas teleconference reduced depressive symptoms more for younger participants (60-64 years) and videoconference increased knowledge for non-White participants as compared to White participants. DISCUSSION: These data suggest that both telephone and videoconference are reasonable options for disclosure of APOE genotype in cognitively unimpaired individuals. Videoconference disclosure may have some benefits for certain demographic groups.