Cutaneous Hypersensitivity and Desensitization to Mechlorethamine in Patients with Mycosis Fungoides Lymphoma

Article1 August 1967Cutaneous Hypersensitivity and Desensitization to Mechlorethamine in Patients with Mycosis Fungoides LymphomaDONALD S. WALDORF, M.D., HARLEY A. HAYNES, M.D., EUGENE J. VAN SCOTT, M.D.DONALD S. WALDORF, M.D., HARLEY A. HAYNES, M.D., EUGENE J. VAN SCOTT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-282 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMechlorethamine (nitrogen mustard, HN2) has been employed in the therapy of mycosis fungoides lymphoma for many years, most often by the intravenous route (1, 2). More recently, the agent has been shown to be effective when applied topically in nonvesicant doses to cutaneous lesions of the disease (3-7). Although development of cutaneous sensitivity to the drug in normal individuals is well-known (5, 8), the frequency of sensitization in patients with mycosis fungoides is alleged to be low (5).The clinical study reported herein was prompted by the observation that allergic contact dermatitis to HN2was induced in 11 of 16...References1. HENSTELLTOBERG HHJN: Treatment of mycosis fungoides with nitrogen mustard. J. Invest. Derm. 8: 183, 1947. CrossrefMedlineGoogle Scholar2. WRIGHTLYONSWALKERGOLOMBGUMPORTMEDREK JCMMDGFMSLTJ: Observations on the use of cancer chemotherapeutic agents in patients with mycosis fungoides. Cancer 17: 1045, 1964. CrossrefMedlineGoogle Scholar3. WILKINSONHASERICK RJ: Topical nitrogen mustard therapy in mycosis fungoides. Arch. Derm. (Chicago) 82: 440, 1960. Google Scholar4. VINEYARDMITCHELL WRDE: Local therapy of mycosis fungoides with cytotoxic agents. A case report. Arch. Derm. (Chicago) 84: 928, 1961. CrossrefMedlineGoogle Scholar5. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONALD S. WALDORF, M.D.; HARLEY A. HAYNES, M.D.; EUGENE J. VAN SCOTT, M.D.Affiliations: Bethesda, MarylandFrom the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Harley A. Haynes, M.D., Dermatology Branch, Bldg. 10, Room 12N-238, National Institutes of Health, Bethesda, Md. 20014. 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Delayed hypersensitivity reaction and the effect of cytotoxic drugsAlterations of lesions of mycosis fungoides lymphoma by direct imposition of delayed hypersensitivity reactions 1 August 1967Volume 67, Issue 2Page: 282-290KeywordsContact dermatitisDermatologyDrugsHypersensitivityLesionsLymphomaMechlorethamine ePublished: 1 December 2008 Issue Published: 1 August 1967 PDF downloadLoading ...